Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. August 22, 2005

They have known this for a very LONG time.

My guess is this post in face book will be taken down, even though nothing stated in  it is false and all information can be found on line.


Virology Journal – the official publication of Dr. Fauci’s National Institutes of Health – published what is now a blockbuster article on August 22, 2005, under the heading – get ready for this – “Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.” Writes the researchers, (Just so there are NO mistakes for the ‘fact checkers’ to dispute THESE ARE THE AUTHORS of this paper — DR. FAUCI DID NOT WRITE OR RESEARCH THE PAPER!)

Affiliations

Special Pathogens Brach, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, 1600 Clifton Road, 30333, USA

Martin J Vincent, Bobbie R Erickson, Pierre E Rollin, Thomas G Ksiazek & Stuart T Nichol

Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, 110 Pine Ave West, QCH2W1R7, Canada

Eric Bergeron, Suzanne Benjannet & Nabil G Seidah

Corresponding author :  Correspondence to Stuart T Nichol.

Additional information

Competing interests

The author(s) declare that they have no competing interests.

Authors’ contributions

MV did all the experiments pertaining to SARS CoV infection and coordinated the drafting of the manuscript. EB and SB performed experiments on ACE2 biosynthesis and FACS analysis. BE performed data acquisition from the immunofluorescence experiments. PR and TK provided critical reagents and revised the manuscript critically. NS and SN along with MV and EB participated in the planning of the experiments, review and interpretation of data and critical review of the manuscript. All authors read and approved the content of the manuscript.

“We report…that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage.”

https://www.orlandomedicalnews.com/article/3397/opinion-letter-from-the-publisher

AND JUST SO THAT WE ARE CLEAR ABOUT THIS POINT:

DR FAUCI IS CURRENTLY THE DIRECTOR OF THE NATIONAL INSTITUTE OF HEALTH, NIH.

About NIAID      Director, Anthony Fauci, M.D.

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Anthony S. Fauci, M.D.

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https://www.niaid.nih.gov/about/directors

 

AND FOR YOUR EDIFICATION HERE ARE THE FIRST THREE PARAGRAPHS OF THE ABSTRACT FROM THE JOURNAL PUBLICATION.

See the link at the bottom of the article for further reading.

 

Research

Open Access

Published: 22 August 2005

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Martin J Vincent, Eric Bergeron, Suzanne Benjannet, Bobbie R Erickson, Pierre E Rollin, Thomas G Ksiazek, Nabil G Seidah & Stuart T Nichol

Virology Journal volume 2, Article number: 69 (2005) Cite this article

 

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Abstract

Background

Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

 

Results

We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

 

Conclusion

Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69

 

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