The insinuation that hydroxychloroquine’s effect might be ‘healing’ broken DNA producing the pre-during-post effects it has on the body’s reaction to SARSCOV2 ‘virus’, (if in deed it is a virus) has been investigated for other functions related to DNA damage, obvious in the patent below. My two dot connections are that: 1.) if it actually does perform by alkalizing the cell insides and surrounding interstitial tissues there by making it impossible for the RNA to replicate by various means, and 2.) does protect the DNA from radiological damage (radio frequency – think 5,6,7G band tech) and chemical toxicity then it would combat two reasons CV19 is able to decimate certain members of the population (toxicity of the body) and block certain frequencies we live in from having a CV19-like effect on the rest of us. (the charts – not included in this blog are VERY revealing and are linked)
To me, IMO, this is further proof of why this drug, hydroxychloroquine, was so speedily blocked from usage.
I have picked choice passages from the google listing of a patent to include below as, I found them very pertinent.
Here is a dosage article on its usage: https://reference.medscape.com/drug/plaquenil-hydroxychloroquine-sulfate-343205
Tonic water contains no more than 83 mg of quinine per liter—a much lower concentration than the 500 to 1,000 mg in the therapeutic dose of quinine tablets. Drinking a few ounces of tonic water shouldn’t be harmful…
SEVEN FACTS ABOUT TONIC WATER
by Stefan Adrian 27. Juli 2017 0 comments
What is tonic water? Here are seven facts about this bitter thirst-quencher that’s mixed most often with gin. Cheers
Even Oasis sang, “I’m feeling supersonic, give me a gin and tonic”. It’s a well-known fact that gin has enjoyed a major comeback in recent years rivaling John Travolta’s reemergence after Pulp Fiction. And some of this renewed acclaim has rightly rubbed off on gin’s own partner-in-crime, tonic water. But what is tonic water exactly? Where does it come from, and what makes it what it is? Here are seven facts on what’s probably the most popular mixer behind the bar.
1) WHAT IS TONIC WATER MADE OF?
In simple terms, classic tonic water is carbonated water infused with quinine. For added taste sometimes sugar or fruit acids are mixed in. The higher the level of quinine in the water, the more bitter it tastes. Quinine comes from the bark of the cinchona tree, which despite its Asian sounding name is actually found in South America. “Tonic” is synonymous with “refresher” or “energizer”, and the Greek root word “tonikos” means “invigorating.”
From a delightful article in Mixology which I highly recommend you go read.
Treatment of radiation disorders
This invention was made in the course of research sponsored by the National Institutes of Health (NIH Grant Nos. CA71387). The U.S. government may have certain rights in this invention.
BACKGROUND OF THE INVENTION
Cancer is now the second leading cause of death in the United States. Over 1 million new cases of cancer are expected to be diagnosed in 2003 and over 500,000 people are expected to die of cancer.
Cancer is typically treated with one or a combination of three types of therapies: surgery, radiation, and chemotherapy. Overall costs for cancer, including treatments, were approximately $170 billion dollars in 2002. The cancer treatments are not only expensive; they are ineffective most of the time and also have many side effects. Hence, there is a demand for more effective cancer prevention and treatment agents, as well as for the prevention and treatment of DNA damage related conditions.
Radiation is all around us. Exposure to radiation includes radiation from natural sources and man-made sources. Acute and/or chronic exposure to radiation causes several adverse effects, including occasionally causing death. The current treatments for treating the adverse effects following exposure to radiation are ineffective most of the time and also have many side effects. Hence, there is a demand for more effective treatment of effects following exposure to radiation.
SUMMARY OF THE INVENTION
The present invention provides compositions, methods, and kits for the treatment and/or prevention of DNA damage related disorders, disorders caused by radiation exposure, and death associated with radiation exposure. In one embodiment, a chloroquine compound is administered for the prevention of DNA damage related disorders, like cancer and radiation related disorders. In another embodiment, the chloroquine compound does not prevent a localized skin cancer alone. In yet another embodiment, the cancers prevented by the chloroquine compounds are a localized skin cancer and a cancer that is not a localized skin cancer. Also described herein are methods of inhibiting the side effects of chemotherapeutic and/or radiotherapeutic agents using chloroquine compounds. Another embodiment is the prevention and/or treatment of lethal or sub-lethal radiation toxicities associated with acts of terrorism or war on response to such acts. The present invention also provides compositions, methods, and kits for use in the treatment of radiation related disorders.
Not intending to be limited by one mechanism, it is believed that the chloroquine compounds and chloroquine like compounds act by enhancing the activity of Ataxia Telangiectasia Mutated (ATM) kinase and downstream events. The agonistic properties of chloroquine on ATM kinase have been demonstrated. Hence, it is intended herein that chloroquine-like compounds include compounds that are agonists of ATM kinase. Agonists of ATM kinase include compounds that promote the dissociation of ATM into active monomers and/or compounds that promote phosphorylation of a serine corresponding to the residue1981ofATMkinase of SEO ID NO:1.
The methods described herein generally involve the administration of effective amounts of chloroquine compounds and/or chloroquine like compounds for the treatment and/or prevention of DNA damage related disorders. The term “DNA damage related disorders’ include, but are not limited to, cancer, aging, disorders caused by damage to DNA due to exposure to carcinogens, toxins, free radicals, like oxygen radical, or DNA damaging radiations like ionizing radiation and UV radiation. The chloroquine compounds are also useful for prevention of tissue injury resulting from ischemia, such as that which occurs following myocardial infarction or Stroke. The effects of the chloroquine compounds used in the methods described herein include systemic, local, and topical effects. It is preferred that the effects of the chloroquine compounds in the methods described herein are systemic.
In one embodiment, the chloroquine compounds are used as prophylactics to prevent DNA damage related disorders. The chloroquine compounds are useful in the prevention of cancers caused by toxins, carcinogens, DNA damaging radiations, and/or genetic mutations. For example, chloroquine compounds are useful in the prevention of cancers caused by exposure to toxins and carcinogens like aromatic hydrocarbons, cigarette smoke, acetylamino fluorine, MTBE, etc. Also, chloroquine compounds are useful in prevention of cancers caused by DNA damaging radiations like UV and ionizing radiation. The ionizing radiations includes both natural and therapeutic radiation exposures. Examples of ionizing radiations are X-rays for diagnostics and radiation therapy used for tumors and unintended exposure to radiation as an act of terrorism or war.
In a preferred embodiment, chloroquine compounds are used in the prevention of one or more of the following cancers—melanomas, prostate cancer, breast cancer, colon cancer, lung cancer, non-Hodgkin’s lymphoma, retinoblastoma, neuroblastoma, sarcomas, and ovarian cancer.
The chloroquine compounds can be used to prevent secondary cancers, i.e., cancers that are caused by radiation therapy and chemotherapy used to treat the primary cancer. In one embodiment, the chloroquine compounds are used to prevent the occurrence of breast cancer in patients receiving radiation therapy for non-Hodgkin’s lymphoma. Also, in these patients the chloroquine compounds can be used to inhibit the cellular damage caused by the radiation therapy to normal cells and enhance the repair process of the normal cells. The chloroquine compounds are also suitable for prevention of the reoccurrence of cancers in patients who have had prior incidences of cancer.
In one embodiment, the chloroquine compounds are administered to decrease or prevent the side-effects of radiation therapy used to treat cancer. The chloroquine compounds can be administered prior to, during, or after treatment with radiation. In this embodiment, the beneficial effect of the chloroquine compounds is contemplated to be not solely limited to a beneficial effect on pathological skin conditions like skin carcinomas and dermatoses. The use of chloroquine compounds in combination with radiation therapy is contemplated to protect the normal cells and inhibit the cellular damage caused by the radiation therapy to normal cells and enhance the repair process of the normal cells.
In one embodiment, the chloroquine compounds are used in immunosuppressed patients, like transplant patients. In immunosuppressed patients, the chloroquine compounds can be used to prevent cancers. The chloroquine compounds can be used to prevent Epstein Barr virus induced lymphoproliferative syndrome.
(How it is intended for use)
1. A method of treatment for a radiation related disorder comprising administering to an animal subject in need thereof an effective amount of a chloroquine compound.
2. The method of claim 1 wherein said radiation related disorder is caused by an exposure to a non-ionizing radiation.
3. The method of claim 1 wherein said radiation related disorder is caused by an exposure to an ionizing radiation.
4. The method of claim 3 wherein said chloroquine compound treats a skin damage symptom caused by said ionizing radiation.
5. The method of claim 4 wherein said skin damage symptom is at least one symptom selected from swelling, itching, redness of skin, and hair loss.
6. The method of claim 3 wherein said chloroquine compound treats a non-skin damage symptom caused by said ionizing radiation.
7. The method of claim 6 wherein said non-skin damage symptom is at least one symptom selected from nausea, vomiting, diarrhea, loss of appetite, fatigue, fever, diminished organ function, seizures, cancer, and coma.
8. The method of claim 1 wherein said radiation related disorder is acute radiation syndrome.
9. The method of claim 1 wherein said chloroquine compound prevents a death due to radiation exposure.
10. The method of claim 1 wherein said chloroquine compound protects from sub-lethal and/or unintentional radiation exposure.
11. The method of claim 1 wherein said chloroquine compound protects from sub-lethal and/or lethal intentional radiation exposure.
12. The method of claim 11 wherein said intentional radiation exposure is due to an act of terrorism.
13. A method of treatment for an adverse effect of a radiation therapy comprising administering to an animal subject in need thereof an effective amount of a chloroquine compound.
14. The method of claim 13 wherein said adverse effect is at least one effect selected from a skin damage, alopecia, or neutropenia.
15. The method of claim 1 or 13 wherein said chloroquine compound is at least one compound selected from chloroquine, chloroquine phosphate, hydroxychloroquine, chloroquine diphosphate, chloroquine sulphate, hydroxychloroquine sulphate, or enantiomers, derivatives, analogs, metabolites, pharmaceutically acceptable salts, and mixtures thereof.
16. The method of claim 15 wherein said compound is at least one compound selected from chloroquine, chloroquine phosphate, hydroxychloroquine, chloroquine diphosphate.
21. The method of claim 1 or 13 wherein the amount of the compound administered is at least about 0.1 mg/kg/day.
22. The method of claim 1 or 13 wherein the amount of the compound administered is up to about 10 mg/kg/day.
27. The method of claim 1 or 13 wherein the chloroquine compound is administered more than once a week.
28. The method claim 1 or 13 wherein the chloroquine compound is administered daily, every two weeks, or once a month.
29. The method of claim 1 or 13 wherein the chloroquine compound is formulated in a sustained release formulation.
30. The method of claim 1 or 13 wherein said amount of said compound administered is about 0.1 to about 9 mg/kg once a week.
It just gets deeper and stinkier…. I encourage you to think on your own, do on your own and investigate everything.